Nebivolol Impurities

The drug nebivolol is used to control and treat high blood pressure.

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Impurity structure Parent Drug Name Name of Impurity Catalogue No. CAS No.
Benzyl Alcohol Benzalkonium Chloride

Benzyl Alcohol

VL3850030 100-51-6
Benzylated Nebivolol Nebivolol

Benzylated Nebivolol

VL490005 N/A
Benzylated Nebivolol Oxylated Salt Nebivolol

Benzylated Nebivolol Oxylated Salt

VE008481 N/A
Des Fluoro FAM Nebivolol Nebivolol

Des Fluoro FAM Nebivolol

VL490025 N/A
Desfluoro FAM Nebivolol Nebivolol

Desfluoro FAM Nebivolol

VE0011629 N/A
Desfluoro Nebivolol impurity Nebivolol

Desfluoro Nebivolol impurity

VE008472 129101-34-4
Di Des Fluoro Nebivolol Nebivolol

Di Des Fluoro Nebivolol

VL490024 N/A
N-Nitroso Nebivolol Nebivolol

N-Nitroso Nebivolol

VE007634 1391051-68-5
N-Nitroso rac-Nebivolol-D4 (Mixture of Diastereomers) Nebivolol

N-Nitroso rac-Nebivolol-D4 (Mixture of Diastereomers)

DVE00940 N/A
Nebivolol D Isomer Nebivolol

Nebivolol D Isomer

VL490012 213132-06-0
Nebivolol Desfluoro Nebivolol

Nebivolol Desfluoro

VL490003 N/A
Nebivolol EP Impurity A Nebivolol

Nebivolol EP Impurity A

VE0011504 N/A
Nebivolol EP Impurity B Nebivolol

Nebivolol EP Impurity B

VE0011506 99200-09-6
Nebivolol EP Impurity C Nebivolol

Nebivolol EP Impurity C

VE0011505 N/A
Nebivolol EP Impurity D Nebivolol

Nebivolol EP Impurity D

VE009079 N/A
Nebivolol FAM Nebivolol

Nebivolol FAM

VL490022 N/A
Nebivolol Impurity 1 Nebivolol

Nebivolol Impurity 1

VL490004 1346562-34-2
Nebivolol Impurity 2 Nebivolol

Nebivolol Impurity 2

VL490014 N/A
Budesonide for System Suitability CRS (Y0001148) Nebivolol

Nebivolol Impurity D CRS (Y0002300)

PVE0079 N/A
Nebivolol Isomer A Nebivolol

Nebivolol Isomer A

VL490008 197706-51-7
Nebivolol Isomer at RRT 0.88 Nebivolol

Nebivolol Isomer at RRT 0.88

VL490006 N/A
Nebivolol Isomer at RRT 1.13 Nebivolol

Nebivolol Isomer at RRT 1.13

VL490007 N/A
Nebivolol Isomer B Nebivolol

Nebivolol Isomer B

VL490009 N/A
Nebivolol L Isomer Nebivolol

Nebivolol L Isomer

VL490013 118457-14-0
Nebivolol Lactose Adduct Nebivolol

Nebivolol Lactose Adduct

VE0010273 N/A
Nebivolol Methyl P Toluene Sulphonate Nebivolol

Nebivolol Methyl P Toluene Sulphonate

VL490010 80-48-8
Nebivolol N-Benzyl Impurity Nebivolol

Nebivolol N-Benzyl Impurity

VE0011628 1199945-26-0
Nebivolol Related Compound A Nebivolol

Nebivolol Related Compound A

VL490001 N/A
Nebivolol Related Compound A (RSSR + SRRS) Nebivolol

Nebivolol Related Compound A (RSSR + SRRS)

VE0011620 N/A
Nebivolol Related Compound B Nebivolol

Nebivolol Related Compound B

VL490002 N/A
Nebivolol Related Compound C Nebivolol

Nebivolol Related Compound C

VE006876 876514-31-7
Nebivolol Related Compound D Nebivolol

Nebivolol Related Compound D

VE006877 793669-26-8
Nebivolol RRRR Nebivolol

Nebivolol RRRR

VL490020 N/A
Nebivolol RRSS Nebivolol

Nebivolol RRSS

VL490023 1360598-84-0
Nebivolol RSRR Nebivolol

Nebivolol RSRR

VL490018 N/A
Nebivolol RSSS Isomer Nebivolol

Nebivolol RSSS Isomer

VL490017 N/A
Nebivolol SRRR Isomer Nebivolol

Nebivolol SRRR Isomer

VL490016 N/A
Nebivolol SRSR and RSRS ISOMER Nebivolol

Nebivolol SRSR and RSRS ISOMER

VL490015 N/A
Nebivolol SRSS Isomer Nebivolol

Nebivolol SRSS Isomer

VL490021 N/A
Nebivolol SSSS ISOMER Nebivolol

Nebivolol SSSS ISOMER

VL490019 N/A
Nebivolol-D4-O-D-Glucuronide (Mixture of Diastereomers) Nebivolol

Nebivolol-D4-O-D-Glucuronide (Mixture of Diastereomers)

DVE00939 N/A
rac N-Benzyl Nebivolol Nebivolol

rac N-Benzyl Nebivolol

VE007764 929706-85-4
(2S, 2’S)-6-Fluoro-2-(2’-oxiranyl)chromane Nebivolol

(2S, 2’S)-6-Fluoro-2-(2’-oxiranyl)chromane

VE008863 129050-23-3

Nebivolol Related Compound

The medicine belongs to the class of beta-blockers.

References

  • Weiss, Robert. “Nebivolol: A Novel Beta-Blocker with Nitric Oxide-Induced Vasodilatation.” Vascular Health and Risk Management, vol. 2, no. 3, Aug. 2006, pp. 303–8, https://doi.org/10.2147/vhrm.2006.2.3.303. Accessed 17 Apr. 2023.
  • “Nebivolol: Uses, Interactions, Mechanism of Action | DrugBank Online.” Drugbank.com, DrugBank, 2013, go.drugbank.com/drugs/DB04861. Accessed 17 Apr. 2023.
  • Hilas, Olga, and Danielle Ezzo. “Nebivolol (Bystolic), a Novel Beta Blocker for Hypertension.” P & T : A Peer-Reviewed Journal for Formulary Management, vol. 34, no. 4, 2009, pp. 188–92, www.ncbi.nlm.nih.gov/pmc/articles/PMC2697096/#:~:text=Nebivolol%20is%20a%20cardioselective%20beta,that%20of%20other%20beta%20blockers. Accessed 17 Apr. 2023. ‌

FAQ

Is nebivolol a selective beta-blocker?

An entirely novel, highly selective beta-blocker with nonadrenergic vasodilating qualities is nebivolol.

What is the mechanism of action of nebivolol?

The beta-3 adrenergic receptor agonist activity of l-nebivolol activates endothelial nitric oxide synthase, raising nitric oxide levels. This causes vasodilation, lower peripheral vascular resistance, stroke volume, ejection fraction, and cardiac output.

What kind of beta-blocker is nebivolol?

A cardioselective beta blocker with approval to treat hypertension is nebivolol. It has distinct vasodilatory effects mediated by nitric oxide, lacks intrinsic sympathomimetic action, and has a tolerance profile that is comparable to other beta blockers.