Nebivolol Impurities

The drug nebivolol is used to control and treat high blood pressure.

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Parent Drug Name Name of Impurity Catalogue No.
Benzalkonium Chloride Benzyl Alcohol VL3850030View CAS 100-51-6
Nebivolol Benzylated Nebivolol VL490005View
Nebivolol Benzylated Nebivolol Oxylated Salt VE008481View
Nebivolol Des Fluoro FAM Nebivolol VL490025View
Nebivolol Desfluoro FAM Nebivolol VE0011629View
Nebivolol Desfluoro Nebivolol impurity VE008472View CAS 129101-34-4
Nebivolol Di Des Fluoro Nebivolol VL490024View
Nebivolol N-Nitroso Nebivolol VE007634View CAS 1391051-68-5
Nebivolol Nebivolol D Isomer VL490012View CAS 213132-06-0
Nebivolol Nebivolol Desfluoro VL490003View
Nebivolol Nebivolol EP Impurity A VE0011504View
Nebivolol Nebivolol EP Impurity B VE0011506View CAS 99200-09-6
Nebivolol Nebivolol EP Impurity C VE0011505View
Nebivolol Nebivolol EP Impurity D VE009079View
Nebivolol Nebivolol FAM VL490022View
Nebivolol Nebivolol Impurity 1 VL490004View CAS 1346562-34-2
Nebivolol Nebivolol Impurity 2 VL490014View
Nebivolol Nebivolol Isomer A VL490008View
Nebivolol Nebivolol Isomer B VL490009View
Nebivolol Nebivolol Isomer at RRT 0.88 VL490006View
Nebivolol Nebivolol Isomer at RRT 1.13 VL490007View
Nebivolol Nebivolol Isopropyl P Toluene Sulphonate VL490011View
Nebivolol Nebivolol L Isomer VL490013View CAS 118457-14-0
Nebivolol Nebivolol Lactose Adduct VE0010273View
Nebivolol Nebivolol Methyl P Toluene Sulphonate VL490010View CAS 80-48-8
Nebivolol Nebivolol N-Benzyl Impurity VE0011628View CAS 1199945-26-0
Nebivolol Nebivolol RRRR VL490020View
Nebivolol Nebivolol RRSS VL490023View CAS 1360598-84-0
Nebivolol Nebivolol RSRR VL490018View
Nebivolol Nebivolol RSSS Isomer VL490017View
Nebivolol Nebivolol Related Compound A VL490001View
Nebivolol Nebivolol Related Compound A (RSSR + SRRS) VE0011620View
Nebivolol Nebivolol Related Compound B VL490002View
Nebivolol Nebivolol Related Compound C VE006876View CAS 876514-31-7
Nebivolol Nebivolol Related Compound D VE006877View CAS 793669-26-8
Nebivolol Nebivolol SRRR Isomer VL490016View
Nebivolol Nebivolol SRSR and RSRS ISOMER VL490015View
Nebivolol Nebivolol SRSS Isomer VL490021View
Nebivolol Nebivolol SSSS ISOMER VL490019View
Nebivolol rac N-Benzyl Nebivolol VE007764View CAS 929706-85-4
Nebivolol (2S, 2’S)-6-Fluoro-2-(2’-oxiranyl)chromane VE008863View CAS 129050-23-3

Nebivolol Related Compound

The medicine belongs to the class of beta-blockers.

References

  • Weiss, Robert. “Nebivolol: A Novel Beta-Blocker with Nitric Oxide-Induced Vasodilatation.” Vascular Health and Risk Management, vol. 2, no. 3, Aug. 2006, pp. 303–8, https://doi.org/10.2147/vhrm.2006.2.3.303. Accessed 17 Apr. 2023.
  • “Nebivolol: Uses, Interactions, Mechanism of Action | DrugBank Online.” Drugbank.com, DrugBank, 2013, go.drugbank.com/drugs/DB04861. Accessed 17 Apr. 2023.
  • Hilas, Olga, and Danielle Ezzo. “Nebivolol (Bystolic), a Novel Beta Blocker for Hypertension.” P & T : A Peer-Reviewed Journal for Formulary Management, vol. 34, no. 4, 2009, pp. 188–92, www.ncbi.nlm.nih.gov/pmc/articles/PMC2697096/#:~:text=Nebivolol%20is%20a%20cardioselective%20beta,that%20of%20other%20beta%20blockers. Accessed 17 Apr. 2023. ‌

FAQ

Is nebivolol a selective beta-blocker?

An entirely novel, highly selective beta-blocker with nonadrenergic vasodilating qualities is nebivolol.

What is the mechanism of action of nebivolol?

The beta-3 adrenergic receptor agonist activity of l-nebivolol activates endothelial nitric oxide synthase, raising nitric oxide levels. This causes vasodilation, lower peripheral vascular resistance, stroke volume, ejection fraction, and cardiac output.

What kind of beta-blocker is nebivolol?

A cardioselective beta blocker with approval to treat hypertension is nebivolol. It has distinct vasodilatory effects mediated by nitric oxide, lacks intrinsic sympathomimetic action, and has a tolerance profile that is comparable to other beta blockers.

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100-51-6: Benzyl Alcohol

100-51-6: Benzyl Alcohol
Catalogue No.

VL3850030
CAS No.

100-51-6
Molecular Formula

C7H8O
Molecular Weight

108.14 g/mol
Parent drug

Benzalkonium Chloride
IUPAC Name

phenylmethanol
Synonyms

Benzylic Alcohol; Phenylmethanol; Benzalkonium Chloride EP Impurity A
References

“HPLC-UV vs. UPLC-DAD for Estimation of Tinidazole, Benzyl Alcohol and Hydrocortisone Acetate Simultaneously with Tioconazole and Its Related Impurities in Bulk and Pharmaceutical Formulations.” Analytical Chemistry Letters, 2017, http://www.tandfonline.com/doi/abs/10.1080/22297928.2017.1308269.? ?Abend, Andreas M., et al. “Concerning the Stability of Benzyl Alcohol: Formation of Benzaldehyde Dibenzyl Acetal under Aerobic Conditions.” Journal of Pharmaceutical and Biomedical Analysis, vol. 34, no. 5, Ma
Status

In-stock
ListName

Benzyl Alcohol
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