Metoprolol Succinate EP Impurity F; Metoprolol Tartarate EP Impurity F; 1-(Isopropylamino)-3-phenoxypropan-2-ol; 1-[(1-Methylethyl)amino]-3-phenoxy-2-propanol; H 9/64; ICI 45849;
Descrição
Metoprolol EP Impurity F (CAS 7695-63-8) | também referido como Metoprolol Succinate EP Impurity F | Metoprolol Tartarate EP Impurity F | 1-(Isopropylamino)-3-phenoxypropan-2-ol | é uma impureza relevante em matérias-primas e fases de síntese do metoprolol. Sua identificação e quantificação são críticas para conformidade farmacopéica; técnicas como HPLC com detecção UV | LC-MS e RMN são empregadas para caracterização estrutural e determinação de limites. A impureza exibe comportamento cromatográfico semelhante ao ativo | exigindo métodos validados com resolução adequada. Estratégias de controle incluem otimização de etapas de síntese | purificação e critérios de especificação para garantir segurança e qualidade do medicamento.
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