Metoprolol EP Impurity A (CAS 109632-08-8) | também conhecida como Metoprolol Related Compound A | Metoprolol Succinate EP Impurity A | C-Desmethyl Metoprolol e N-Desisopropyl-N-ethylmetoprolol | é um derivado desmetilado/dealquilado do metoprolol que surge como subproduto durante etapas de síntese e purificação. Caracteriza-se por maior lipofilicidade relativa e perfil cromatográfico distinto | exigindo monitoramento por HPLC com detecção UV e confirmação por LC-MS/MS para garantir conformidade com especificações farmacopéicas. A identificação estrutural por RMN e espectrometria de massas suporta controles de qualidade e desenvolvimento de processos que minimizam sua formação | avaliando rendimento | reagentes e condições de reação.
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