Metoprolol Related Compound B (CAS 56718-76-4) | 1-Cloro-3-[4-(2-metoxietil)fenoxi]-2-propanol | é uma impureza conhecida em matéria-prima e lotes de desenvolvimento de metoprolol | originada por reações secundárias de cloração ou por contaminação durante a síntese. A identificação e quantificação dessa impureza são críticas para controle de qualidade e conformidade com ICH Q3A/B | usando técnicas analíticas como HPLC com detecção UV | LC-MS e RMN para confirmação estrutural. Sua presença pode afetar pureza | perfil de degradados e estabilidade do produto. Estratégias de minimização incluem otimização de etapas reacionais | controles de processo e limites analíticos estabelecidos nas especificações.
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