384329-76-4: Abacavir-5′-glucuronide

Status: Under Development

Abacavir-5′-glucuronide (CAS No: 384329-76-4) is one of the major metabolites of Abacavir which is a nucleoside analog, HIV-1 reverse transcriptase inhibitor, and a potent in vivo and in vitro inhibitor of HIV-1 that causes acquired immunodeficiency syndrome.

Additional information on CAS 384329-76-4

Catalogue No. VL760019
CAS No. 384329-76-4
Molecular Formula C20H26N6O7
Molecular Weight 462.47 g/mol
Parent drug Abacavir
IUPAC Name (2S, 3S, 4S, 5R)-6-((4-(2-amino-6-(cyclopropylamino)-9H-purin-9-yl)cyclopent-2-en-1-yl)methoxy)-3, 4, 5-trihydroxytetrahydro-2H-pyran-2-carboxylic acid
Pharmacopoeial Synonyms N/A
Other Synonyms Abacavir 5'-beta-D-Glucuronide; Abacavir glucuronide; abacavir glucosiduronic acid; Abacavir 5'-glucosiduronic acid; ABACAVIR 5'-B-D-GLUCURONIDE; (2S,3S,4S,5R,6R)-6-[[(1S,4R)-4-[2-amino-6-(cyclopropylamino)purin-9-yl]cyclopent-2-en-1-yl]methoxy]-3,4,5-trihydroxyoxane-2-carboxylic acid; ((1S,4R)-4-(2-Amino-6-(cyclopropylamino)-9H-purin-9-yl)-2-cyclopenten-1-yl)methyl beta-D-glucopyranosiduronic acid beta-D-Glucopyranosiduronic acid; ((1S,4R)-4-(2-amino-6-(cyclopropylamino)-9H-purin-9-yl)-2-cyclopenten-1-yl)methyl; {(1S,4R)-4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]cyclopent-2-en-1-yl}methyl beta-D-glucopyranosiduronic acid; ((1S,4R)-4-(2-AMINO-6-(CYCLOPROPYLAMINO)-9H-PURIN-9-YL)-2-CYCLOPENTEN-1-YL)METHYL .BETA.-D-GLUCOPYRANOSIDURONIC ACID; (2S,3S,4S,5R,6R)-6-(((1S,4R)-4-(2-Amino-6-(cyclopropylamino)-9H-purin-9-yl)cyclopent-2-en-1-yl)methoxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic acid
References Ravitch, Joshua R., and Caroline G. Moseley. “High-Performance Liquid Chromatographic Assay for Abacavir and Its Two Major Metabolites in Human Urine and Cerebrospinal Fluid.” Journal of Chromatography B: Biomedical Sciences and Applications, vol. 762, no. 2, Oct. 2001, pp. 165–73, https://doi.org/10.1016/s0378-4347(01)00361-9.
Status Under Development

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384329-76-4: Abacavir-5′-glucuronide

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