1443421-69-9: Abacavir EP Impurity B

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Abacavir EP Impurity B (CAS No: 1443421-69-9) or Abacavir O-Pyrimidine Impurity / Abacavir Related Compound D is synthesized by degradation of Abacavir which is a nucleoside reverse transcriptase inhibitor and Its mechanism include chain termination subsequent to incorporation into the growing polynucleotide strand. It is used in the treatment of HIV infection.

Additional information on CAS 1443421-69-9

Catalogue No. VL760001
CAS No. 1443421-69-9
Molecular Formula C18H21ClN10O
Molecular Weight 428.8 g/mol
Parent drug Abacavir
IUPAC Name 6-(Cyclopropylamino)-9-[(1R, 4S)-4-[[(2, 5-diamino-6-chloropyrimidin-4-yl)oxy]methyl]cyclopent-2-enyl]-9H-purine-2-amine
Pharmacopoeial Synonyms O-Pyrimidine Derivative Abacavir; Abacavir Related Compound D
Other Synonyms Abacavir 5'-4-Chloro-6-methylpyrimidine-2,5-diamine; 6-N-cyclopropyl-9-[(1R,4S)-4-[(2,5-diamino-6-chloropyrimidin-4-yl)oxymethyl]cyclopent-2-en-1-yl]purine-2,6-diamine; N6-Cyclopropyl-9-((1R,4S)-4-(((2,5-diamino-6-chloropyrimidin-4-yl)oxy)methyl)cyclopent-2-en-1-yl)-9H-purine-2,6-diamine; N6-Cyclopropyl-9-((1R,4S)-4-((2,5-diamino-6-chloropyrimidin-4-yloxy)methyl)cyclopent-2-enyl(-9H-purine-2,6 diamine; 9H-PURINE-2,6-DIAMINE, N6-CYCLOPROPYL-9-((1R,4S)-4-(((2,5-DIAMINO-6-CHLORO-4-PYRIMIDINYL)OXY)METHYL)-2-CYCLOPENTEN-1-YL)-
References Kurmi, Moolchand, et al. “Stability Behaviour of Antiretroviral Drugs and Their Combinations. 5: Characterization of Novel Degradation Products of Abacavir Sulfate by Mass and Nuclear Magnetic Resonance Spectrometry.” Journal of Pharmaceutical and Biomedical Analysis, vol. 134, Feb. 2017, pp. 372–84, https://doi.org/10.1016/j.jpba.2016.10.019. ?Vukkum, Pallavi. “Stress Degradation Behavior of Abacavir Sulfate and Development of a Suitable Stability-Indicating UHPLC Method for the Determination
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