Abacavir Impurities

Abacavir is used in the treatment of human immunodeficiency virus (HIV) infection in conjunction with other medications.

Show
per page
Impurity structure Parent Drug Name Name of Impurity Catalogue No. CAS No.
Abacavir 5’-Phosphate Abacavir

Abacavir 5’-Phosphate

VL760020 136470-77-4
Abacavir Carboxylate Abacavir

Abacavir Carboxylate

VL760021 384380-52-3
Abacavir Cyclopropyl Diamino Purine Impurity Abacavir

Abacavir Cyclopropyl Diamino Purine Impurity

VL760002 120503-69-7
Abacavir D4 Abacavir

Abacavir D4

DVE0089 1260619-56-4
Abacavir EP Impurity A Abacavir

Abacavir EP Impurity A

VL760013 136470-79-6
Abacavir EP Impurity B Abacavir

Abacavir EP Impurity B

VL760001 1443421-69-9
Abacavir EP Impurity C Abacavir

Abacavir EP Impurity C

VL760006 124752-25-6
Abacavir EP Impurity D (Free Base) Abacavir

Abacavir EP Impurity D (Free Base)

VE0010465 783292-37-5
Abacavir EP Impurity D (HCl Salt) Abacavir

Abacavir EP Impurity D (HCl Salt)

VL760005 267668-71-3
Abacavir EP Impurity E Abacavir

Abacavir EP Impurity E

VL760014 208762-35-0
Abacavir EP Impurity F Abacavir

Abacavir EP Impurity F

VL760003 1443421-68-8
Abacavir Ethanolate Impurity Abacavir

Abacavir Ethanolate Impurity

VL760004 N/A
Abacavir Impurity 1 Abacavir

Abacavir Impurity 1

VL760011 2022943-79-7
Abacavir Impurity 3 (HCl Salt) Abacavir

Abacavir Impurity 3 (HCl Salt)

VE0012173 168960-19-8
Abacavir Impurity 4 Abacavir

Abacavir Impurity 4

VL760015 N/A
Abacavir Impurity 5 Abacavir

Abacavir Impurity 5

VL760016 N/A
Abacavir Impurity 6 Abacavir

Abacavir Impurity 6

VL760017 N/A
Abacavir Impurity 7 Abacavir

Abacavir Impurity 7

VE0011535 171887-01-7
Abacavir Impurity 8 Abacavir

Abacavir Impurity 8

VE0011536 171887-02-8
Abacavir Methanolate Impurity Abacavir

Abacavir Methanolate Impurity

VE008660 N/A
Abacavir N-Oxide Impurity Abacavir

Abacavir N-Oxide Impurity

VL760010 1443421-70-2
Abacavir Nitroso 1 Abacavir

Abacavir Nitroso 1

VE007065 N/A
Abacavir Related Compound B Abacavir

Abacavir Related Compound B

VL760025 141271-12-7
Abacavir Related Compound C Abacavir

Abacavir Related Compound C

VL760026 172015-79-1
Abacavir-1-O-pyrimidine Derivative Abacavir

Abacavir-1-O-pyrimidine Derivative

VE008692 N/A
Abacavir-5'-glucuronide Abacavir

Abacavir-5'-glucuronide

VL760019 384329-76-4
ABCRC-1 Dinitroso Impurity Abacavir

ABCRC-1 Dinitroso Impurity

VE007759 N/A
ABCRC-1 Nitroso Impurity-1 Abacavir

ABCRC-1 Nitroso Impurity-1

VE007757 N/A
ABCRC-1 Nitroso Impurity-2 Abacavir

ABCRC-1 Nitroso Impurity-2

VE007758 N/A
Avermectin B1a Monosaccharide Abacavir

Avermectin B1a Monosaccharide

VL4970010 71831-09-9
Clorabacavir Racemic Abacavir

Clorabacavir Racemic

VL760012 1918156-05-4
Decitabine Urea Impurity Abacavir

Decitabine Urea Impurity

VL760027 570410-72-9
Ethacrynic Acid Impurity 1 Ethacrynic Acid

Ethacrynic Acid Impurity 1

VE0015370 N/A
N-(2-amino-4-chloro-6-(((1R,4S)-4-(hydroxymethyl)cyclopent-2-en-1-yl)amino)pyrimidin-5-yl)formamide Abacavir

N-(2-amino-4-chloro-6-(((1R,4S)-4-(hydroxymethyl)cyclopent-2-en-1-yl)amino)pyrimidin-5-yl)formamide

VE0019828 171887-04-0
N-(4-(hydroxymethyl)cyclopent-2-enyl)acetamide Abacavir

N-(4-(hydroxymethyl)cyclopent-2-enyl)acetamide

VE009166 N/A
N-Nitroso Abacavir Abacavir

N-Nitroso Abacavir

VE0011534 N/A
Prucalopride-N-Galactopyranoside Abacavir

Prucalopride-N-Galactopyranoside

VL760028 N/A
Trans - Aminocarbinol Abacavir

Trans - Aminocarbinol

VE008534 N/A
((1R,4S)-4-aminocyclopent-2-en-1-yl)methanol Tartrate Abacavir

((1R,4S)-4-aminocyclopent-2-en-1-yl)methanol Tartrate

VE0019825 N/A
((1S,4R)-4-(2-amino-6-chloro-9H-purin-9-yl)cyclopent-2-enyl)methyl formate Abacavir

((1S,4R)-4-(2-amino-6-chloro-9H-purin-9-yl)cyclopent-2-enyl)methyl formate

VE009171 N/A
3 Hydroxy Abacavir Abacavir

3 Hydroxy Abacavir

VL760008 N/A
3-Hydroxy Ipratropium Bromide Ipratropium

3-Hydroxy Ipratropium Bromide

VE0015400 N/A

Abacavir Related Compound

The HIV virus is the cause of acquired immunodeficiency syndrome (AIDS).

References

  • “Abacavir (Ziagen): Basics, Side Effects & Reviews.” GoodRx, 28 Nov. 2020, www.goodrx.com/abacavir/what-is.
  • Yuen, Geoffrey J., et al. “A Review of the Pharmacokinetics of Abacavir.” Clinical Pharmacokinectics, vol. 47, no. 6, Adis, Springer Healthcare, Jan. 2008, pp. 351–71, https://doi.org/10.2165/00003088-200847060-00001. Accessed 27 Oct. 2023.
  • ‌Joseph, D., et al. “HLA-B*5701 Testing to Predict Abacavir Hypersensitivity.” PLOS Currents, vol. 2, Public Library of Science, Dec. 2010, pp. RRN1203–3, https://doi.org/10.1371/currents.rrn1203. Accessed 27 Oct. 2023.

FAQ’s

What is the generic name of abacavir?

Abacavir (Ziagen) is a reverse transcriptase inhibitor containing nucleosides (NRTI).

What is abacavir's half-life?

Abacavir has a terminal elimination half-life of around 1.5 hours. The antiviral activity of abacavir is related to its intracellular anabolite, carbovir-triphosphate (CBV-TP).

Does abacavir cause hypersensitivity?

Abacavir can cause a treatment-limiting hypersensitivity response, which can be severe and potentially lethal.