Abacavir Impurities

Abacavir is used in the treatment of human immunodeficiency virus (HIV) infection in conjunction with other medications.

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Impurity structure Parent Drug Name Name of Impurity Catalogue No. CAS No.
Abacavir 5’-Phosphate Abacavir

Abacavir 5’-Phosphate

VL760020 136470-77-4
Abacavir Carboxylate Abacavir

Abacavir Carboxylate

VL760021 384380-52-3
Abacavir Cyclopropyl Diamino Purine Impurity Abacavir

Abacavir Cyclopropyl Diamino Purine Impurity

VL760002 120503-69-7
Abacavir D4 Abacavir

Abacavir D4

DVE0089 1260619-56-4
Abacavir EP Impurity A Abacavir

Abacavir EP Impurity A

VL760013 136470-79-6
Abacavir EP Impurity B Abacavir

Abacavir EP Impurity B

VL760001 1443421-69-9
Abacavir EP Impurity C Abacavir

Abacavir EP Impurity C

VL760006 124752-25-6
Abacavir EP Impurity D (Free Base) Abacavir

Abacavir EP Impurity D (Free Base)

VE0010465 783292-37-5
Abacavir EP Impurity D (HCl Salt) Abacavir

Abacavir EP Impurity D (HCl Salt)

VL760005 267668-71-3
Abacavir EP Impurity E Abacavir

Abacavir EP Impurity E

VL760014 208762-35-0
Abacavir EP Impurity F Abacavir

Abacavir EP Impurity F

VL760003 1443421-68-8
Abacavir Ethanolate Impurity Abacavir

Abacavir Ethanolate Impurity

VL760004 N/A
Abacavir Impurity 1 Abacavir

Abacavir Impurity 1

VL760011 2022943-79-7
Abacavir Impurity 3 (HCl Salt) Abacavir

Abacavir Impurity 3 (HCl Salt)

VE0012173 168960-19-8
Abacavir Impurity 4 Abacavir

Abacavir Impurity 4

VL760015 N/A
Abacavir Impurity 5 Abacavir

Abacavir Impurity 5

VL760016 N/A
Abacavir Impurity 6 Abacavir

Abacavir Impurity 6

VL760017 N/A
Abacavir Impurity 7 Abacavir

Abacavir Impurity 7

VE0011535 171887-01-7
Abacavir Impurity 8 Abacavir

Abacavir Impurity 8

VE0011536 171887-02-8
Abacavir Methanolate Impurity Abacavir

Abacavir Methanolate Impurity

VE008660 N/A
Abacavir N-Oxide Impurity Abacavir

Abacavir N-Oxide Impurity

VL760010 1443421-70-2
Abacavir Nitroso 1 Abacavir

Abacavir Nitroso 1

VE007065 N/A
Abacavir Related Compound B Abacavir

Abacavir Related Compound B

VL760025 141271-12-7
Abacavir Related Compound C Abacavir

Abacavir Related Compound C

VL760026 172015-79-1
Abacavir-1-O-pyrimidine Derivative Abacavir

Abacavir-1-O-pyrimidine Derivative

VE008692 N/A
Abacavir-5'-glucuronide Abacavir


VL760019 384329-76-4
ABCRC-1 Dinitroso Impurity Abacavir

ABCRC-1 Dinitroso Impurity

VE007759 N/A
ABCRC-1 Nitroso Impurity-1 Abacavir

ABCRC-1 Nitroso Impurity-1

VE007757 N/A
ABCRC-1 Nitroso Impurity-2 Abacavir

ABCRC-1 Nitroso Impurity-2

VE007758 N/A
Avermectin B1a Monosaccharide Abacavir

Avermectin B1a Monosaccharide

VL4970010 71831-09-9
Clorabacavir Racemic Abacavir

Clorabacavir Racemic

VL760012 1918156-05-4
Decitabine Urea Impurity Abacavir

Decitabine Urea Impurity

VL760027 570410-72-9
Ethacrynic Acid Impurity 1 Ethacrynic Acid

Ethacrynic Acid Impurity 1

VE0015370 N/A
N-(2-amino-4-chloro-6-(((1R,4S)-4-(hydroxymethyl)cyclopent-2-en-1-yl)amino)pyrimidin-5-yl)formamide Abacavir


VE0019828 171887-04-0
N-(4-(hydroxymethyl)cyclopent-2-enyl)acetamide Abacavir


VE009166 N/A
N-Nitroso Abacavir Abacavir

N-Nitroso Abacavir

VE0011534 N/A
Prucalopride-N-Galactopyranoside Abacavir


VL760028 N/A
Trans - Aminocarbinol Abacavir

Trans - Aminocarbinol

VE008534 N/A
((1R,4S)-4-aminocyclopent-2-en-1-yl)methanol Tartrate Abacavir

((1R,4S)-4-aminocyclopent-2-en-1-yl)methanol Tartrate

VE0019825 N/A
((1S,4R)-4-(2-amino-6-chloro-9H-purin-9-yl)cyclopent-2-enyl)methyl formate Abacavir

((1S,4R)-4-(2-amino-6-chloro-9H-purin-9-yl)cyclopent-2-enyl)methyl formate

VE009171 N/A
3 Hydroxy Abacavir Abacavir

3 Hydroxy Abacavir

VL760008 N/A
3-Hydroxy Ipratropium Bromide Ipratropium

3-Hydroxy Ipratropium Bromide

VE0015400 N/A

Abacavir Related Compound

The HIV virus is the cause of acquired immunodeficiency syndrome (AIDS).


  • “Abacavir (Ziagen): Basics, Side Effects & Reviews.” GoodRx, 28 Nov. 2020, www.goodrx.com/abacavir/what-is.
  • Yuen, Geoffrey J., et al. “A Review of the Pharmacokinetics of Abacavir.” Clinical Pharmacokinectics, vol. 47, no. 6, Adis, Springer Healthcare, Jan. 2008, pp. 351–71, https://doi.org/10.2165/00003088-200847060-00001. Accessed 27 Oct. 2023.
  • ‌Joseph, D., et al. “HLA-B*5701 Testing to Predict Abacavir Hypersensitivity.” PLOS Currents, vol. 2, Public Library of Science, Dec. 2010, pp. RRN1203–3, https://doi.org/10.1371/currents.rrn1203. Accessed 27 Oct. 2023.


What is the generic name of abacavir?

Abacavir (Ziagen) is a reverse transcriptase inhibitor containing nucleosides (NRTI).

What is abacavir's half-life?

Abacavir has a terminal elimination half-life of around 1.5 hours. The antiviral activity of abacavir is related to its intracellular anabolite, carbovir-triphosphate (CBV-TP).

Does abacavir cause hypersensitivity?

Abacavir can cause a treatment-limiting hypersensitivity response, which can be severe and potentially lethal.