1443421-70-2: Abacavir N-Oxide Impurity

Status: Under Development

Abacavir N-Oxide Impurity (CAS No: 1443421-70-2) is formed by the degradation of Abacavir. Abacavir is a nucleoside analog reverse transcriptase inhibitor that inhibits isolates of HIV in vitro with a potency similar to that of zidovudine for the treatment of HIV-infected patients.

Additional information on CAS 1443421-70-2

Catalogue No. VL760010
CAS No. 1443421-70-2
Molecular Formula C14H18N6O2
Molecular Weight 302.34 g/mol
Parent drug Abacavir
IUPAC Name (1S,4R )-[4-[2-Amino-6-( cyclopropyl amino)-7-oxo-9H-purine-9-yl]cyclopent-2-en-1-yl]methanol
Pharmacopoeial Synonyms N/A
Other Synonyms (1S,4R)-4-(2-Amino-6-(cyclopropylamino)-7-oxido-9H-purin-9-yl)-2-cyclopentene-1-methanol; 2-Cyclopentene-1-methanol, 4-(2-amino-6-(cyclopropylamino)-7-oxido-9H-purin-9-yl)-, (1S,4R)-
References Foster RH, Faulds D. Abacavir. Drugs. 1998 May;55(5):729-36; discussion 737-8. DOI: 10.2165/00003495-199855050-00018. PMID: 9585869. ?Vukkum, Pallavi. “Stress Degradation Behavior of Abacavir Sulfate and Development of a Suitable Stability-Indicating UHPLC Method for the Determination of Abacavir, Its Related Substances, and Degradation Products.” Scientia Pharmaceutica, vol. 80, no. 4, 2012, pp. 903–21, https://doi.org/10.3797/scipharm.1206-11.
Status Under Development

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